Moyle GJ. Resistance to antiretroviral compounds: implications for the clinical management of HIV infection. Immunol Infect Dis. Pfizer. Vfend voriconazole prescribing information. New York, NY; 2011 Nov. The pharmacokinetic profiles of indinavir at this dose were not comparable to profiles previously observed in adults receiving the recommended dose see . Although viral suppression was observed in some of the 32 children who were followed on this regimen through 24 weeks, a substantially higher rate of nephrolithiasis was reported when compared to adult historical data see . Physicians considering the use of indinavir in pediatric patients without other protease inhibitor options should be aware of the limited data available in this population and the increased risk of nephrolithiasis.
Indinavir pharmacokinetic parameters in these women were compared to those in HIV seropositive men pooled historical control data. Protect from moisture. 1 Dispense and store in original container; the desiccant should remain in the original bottle. Mitotane: May decrease the serum concentration of CYP3A4 Substrates. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane.
HIV-1 protease inhibitor, in human urine. Drug Metab Dispos. It works by slowing or stopping the growth of or tumor cells. Rachline A, Lariven S, Descamps V, Grossin M, Bouvet E "Leucocytoclastic vasculitis and indinavir. Prophylaxis should be initiated immediately, preferably within hours after exposure. What other drugs will affect indinavir? Indinavir is best taken with water on an empty stomach 1 hour before or 2 hours after a meal. Alternatively, it may be taken with other liquids or a light meal dry toast with jelly, juice, coffee with skim milk and sugar, or corn flakes with skim milk and sugar. It should not be taken with a high calorie, fat, or protein meal because absorption is reduced.
Race E, Dam E, Obry V et al. Analysis of HIV cross-resistance to protease inhibitors using a rapid single-cycle recombinant virus assay for patients failing on combination therapies. AIDS. Beekman SE, Henderson DK. HIV infection in healthcare workers: risks for infection and methods of prevention. Semin Dermatol. Dose reduction of rifabutin to half the standard dose and a dose increase of CRIXIVAN to 1000 mg every 8 hours are recommended when rifabutin and CRIXIVAN are coadministered. This information should not be used to decide whether or not to take indinavir or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about indinavir. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to indinavir. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using indinavir.
Everolimus has rarely caused very serious possibly fatal problems. Tell your doctor right away if you develop signs of problems, such as a change in the amount of urine. Yeh KC, Deutsch PJ, Haddix H et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. How should I take Crixivan indinavir? Grases F, Garcia-Gonzalez R, Redondo E, et al. "Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. If you take didanosine, ask your doctor or pharmacist how to take it with indinavir. These effects may be worse if you take it with alcohol or certain medicines. The mechanism and long-term consequences of these events are currently unknown. A causal relationship has not been established. Lovastatin: Protease Inhibitors may increase the serum concentration of Lovastatin. Delta Coordinating Committee. Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet.
Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring. Adverse events were observed in some animal reproduction studies. Placental passage in humans with unboosted dosing is minimal. No increased risk of overall birth defects has been observed according to data collected by the antiretroviral pregnancy registry. A small increased risk of preterm birth has been associated with maternal use of protease inhibitor-based combination antiretroviral therapy during pregnancy; however, the benefits of use generally outweigh this risk and protease inhibitors PIs should not be withheld if otherwise recommended. Information related to stillbirth, low birth weight, and small for gestational age infants is limited. Long-term follow-up is recommended for all infants exposed to antiretroviral medications; children who develop significant organ system abnormalities of unknown etiology particularly of the CNS or heart should be evaluated for potential mitochondrial dysfunction. Hyperbilirubinemia may occur in neonates following in utero exposure to indinavir. Hyperglycemia, new onset of diabetes mellitus, or diabetic ketoacidosis have been reported with PIs; it is not clear if pregnancy increases this risk. Hyperbilirubinemia reported in patients receiving indinavir; 1 4 17 23 201 because of risk associated with hyperbilirubinemia kernicterus some experts state do not use in neonates. Do not have any kind of sex without protection. Dapoxetine: CYP3A4 Inhibitors Strong may increase the serum concentration of Dapoxetine. Crixivan Capsules are sensitive to moisture. Crixivan should be dispensed and stored in the original container. The desiccant should remain in the original bottle. Tadalafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Tadalafil. ZERIT may be required if toxicity develops.
What should I discuss with my healthcare provider before taking alosetron Lotronex? Symptoms may continue or worsen following discontinuation of therapy. H2-Antagonists: May decrease the serum concentration of Indinavir. Stribild elvitegravir, cobicistat, emtricitabine, tenofovir prescribing information. Gilead Sciences, Inc. February, 2016. Concomitant use of trazodone and Crixivan may increase plasma concentrations of trazodone. Adverse events of nausea, dizziness, hypotension and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as Crixivan, the combination should be used with caution and a lower dose of trazodone should be considered. Take this medication exactly as prescribed. not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. This medicine should not be given to a child younger than 18 years old. Almotriptan: CYP3A4 Inhibitors Strong may increase the serum concentration of Almotriptan. Colchicine: CYP3A4 Inhibitors Strong may increase the serum concentration of Colchicine. Management: Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a strong CYP3A4 inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed.
Consider discontinuing indinavir in patients with severe leukocyturia. Levy JA. Surrogate markers in AIDS research: is there truth in numbers? Crixivan does not cure HIV infection or AIDS and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. You should remain under the care of a doctor when using Crixivan. Etravirine: Protease Inhibitors may decrease the serum concentration of Etravirine. This effect is anticipated with darunavir, saquinavir, and lopinavir with low-dose ritonavir. Etravirine may increase the serum concentration of Protease Inhibitors. This effect is anticipated with nelfinavir. Management: Low-dose ritonavir boosting must be used when any protease inhibitor is used with etravirine. Avoid use of etravirine in combination with atazanavir, fosamprenavir, full-dose ritonavir 600 mg twice daily, in adults or tipranavir. The body breaks down antipyrine to get rid of it. Some chemicals in marijuana might decrease how quickly the body breaks down antipyrine. This might increase antipyrine levels in the body and increase its effects and side effects. ONGLYZA and periodically thereafter. St. John's wort, drugs used to treat such as phenytoin among others.
Dose reduction of rifabutin to half the standard dose and a dose increase of Crixivan to 1000 mg every 8 hours are recommended when rifabutin and Crixivan are coadministered. Company Inc, West Point, PA: Personal communication. ViiV Healthcare. Lexiva fosamprenavir calcium tablets and oral suspension prescribing information. Research Triangle Park, NC; 2012 Feb. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using indinavir while you are pregnant. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or indinavir to the baby. It is not known if this medicine is found in breast milk. New-onset diabetes mellitus, hyperglycemia, exacerbation of existing diabetes, and increased serum cholesterol have been reported during postmarketing experience. Frequency not always defined. Adverse reaction statistics have been compiled from studies including patients with advanced HIV disease. Consequently, it is difficult to distinguish reactions attributed to atovaquone from those caused by the underlying disease or a combination thereof. Collin F, Chene G, Retout S, et al. "Indinavir Trough Concentration as a Determinant of Early Nephrolithiasis in HIV-1-Infected Adults. Lichtenstein KA, Ward DJ, Moorman AC, et al. "Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine.
Studies in lactating rats have demonstrated that indinavir is excreted in milk. Although it is not known whether Crixivan is excreted in human milk, there exists the potential for adverse effects from indinavir in nursing infants. Mothers should be instructed to discontinue nursing if they are receiving Crixivan. ONGLYZA were 65 years and over, and 1210 10. Indinavir may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Ingestion of Crixivan with a meal high in calories, fat, and protein reduces the absorption of indinavir. Pharmaceuticals, Inc. September, 2016. AUC values in subjects with normal renal function. PCP were eligible for enrollment. Concomitant ketoconazole: Dose reduction of indinavir to 600 mg orally every 8 hours is recommended. Midostaurin: CYP3A4 Inhibitors Strong may increase the serum concentration of Midostaurin. Management: Seek alternatives to the concomitant use of midostaurin and strong CYP3A4 inhibitors if possible. If concomitant use cannot be avoided, monitor patients for increased risk of adverse reactions. As your gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time soon after starting or many months later.
Using indinavir with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Saez-Llorens X, Ramilo O. Early experience with protease inhibitors in human immunodeficiency virus-infected children. Dieleman JP, vanderFeltz M, Bangma CH, Stricker BHC, vanderEnde ME "Papillary necrosis associated with the HIV protease inhibitor indinavir. Not all side effects for indinavir may be reported. You should always consult a doctor or healthcare professional for medical advice. Salahuddin S, Kok DJ, Buchholz NN "Influence of body temperature on indinavir crystallization under loop of Henle conditions. Dasatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Dasatinib. Management: Use of this combination should be avoided; consider reducing dasatinib dose if a strong CYP3A4 inhibitor must be used. How should I take alosetron Lotronex? CYP3A inhibitor is no longer needed. What happens if I miss a dose Lotronex? Zolpidem: CYP3A4 Inhibitors Strong may increase the serum concentration of Zolpidem. HIV-infected women not planning a pregnancy may use any available type of contraception, considering possible drug interactions and contraindications of the specific method. In addition, consistent use of condoms is also recommended even during pregnancy to prevent transmission of HIV or other sexually transmitted diseases. Caucasians 26 HIV-positive and 16 Blacks 4 HIV-positive. Vivus. Stendra avanafil tablets prescribing information. Mountain View, CA; 2012 Apr.
Registered trademark of Pfizer, Inc. Registered trademark of Eli Lilly and Company. Do not take alosetron if you are also taking fluvoxamine Luvox to treat obsessive-compulsive disorder. RifAMPin: May decrease the serum concentration of Indinavir. Monpoux F, Sirvent N, Cottalorda J et al. Stavudine, lamivudine and indinavir in children with advanced HIV-1 infection: preliminary experience. AIDS. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.
Gastrointestinal disorders: Consider parenteral therapy with alternative agents in patients who have difficulty taking atovaquone with food. Gastrointestinal disorders may limit absorption of oral medications; may not achieve adequate plasma levels. Registered trademark of Ortho Pharmaceutical Corporation. The study enrolled 1156 HIV-infected patients 17% female, 28% Black, 18% Hispanic, mean age 39 years. According to the manufacturer, indinavir was identified as a component of the kidney stones from 8 of 12 patients in whom nephrolithiasis developed. It is not known whether an additional risk is incurred with the concomitant use of crystalluria-inducing medications such as sulfonamides. Stop taking alosetron if your IBS symptoms do not improve after 4 weeks of treatment. If you stop taking alosetron, do not start taking it again without your doctor's advice. Indinavir is usually taken every 8 hours around the clock. Take the medicine at the same time each day. Eastone JA, Decker CF. New-onset diabetes mellitus associated with use of protease inhibitor. Ann Intern Med. DOXOrubicin Conventional: CYP3A4 Inhibitors Strong may increase the serum concentration of DOXOrubicin Conventional. Management: Seek alternatives to strong CYP3A4 inhibitors in patients treated with doxorubicin whenever possible.
Budesonide Nasal: CYP3A4 Inhibitors Strong may increase the serum concentration of Budesonide Nasal. Delavirdine: Protease Inhibitors may decrease the serum concentration of Delavirdine. Delavirdine may increase the serum concentration of Protease Inhibitors. HIV protease inhibitor: pharmacokinetics, tolerability and short-term antiviral activity. Clin Res. Older adults may be more sensitive to the side effects of this drug. Meperidine. Protease Inhibitors may decrease the serum concentration of Meperidine. Concentrations of the toxic Normeperidine metabolite may be increased. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach. CRIXIVAN. There is increased potential for sildenafil-associated adverse events which include visual disturbances, hypotension, prolonged erection, and syncope. Mellors JW, McMahon DK, Chodakewitz JA et al. Correlation between genotypic evidence of HIV-1 resistance to the protease inhibitor MK-639 and loss of anti-retroviral effect in treated patients. J Acquir Immune Defic Syndr Hum Retrovirol. Prophylaxis should be initiated immediately, preferably within hours after exposure. Everolimus can commonly cause a mild that is usually not serious. CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed. What should I discuss with my healthcare provider before taking indinavir? Diabetes: Changes in glucose tolerance, hyperglycemia, exacerbation of diabetes, DKA, and new-onset diabetes mellitus have been reported in patients receiving protease inhibitors.
Available as indinavir sulfate; dosage expressed as indinavir. SORAfenib: CYP3A4 Inhibitors Strong may increase the serum concentration of SORAfenib. Increases in bilirubin one laboratory test of liver function have been reported in approximately 14% of patients. Usually, this finding has not been associated with liver problems. ZERIT with didanosine, lamivudine, and nelfinavir. Indinavir may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection eg, fever, sore throat, weakness, cough, shortness of breath after you start indinavir. MorrisonGriffiths S, Newman M, OMahony C, Pirmohamed M "Adverse drug reaction of the month - Haemolytic anaemia associated with indinavir. Maness LJ, Blair DC, Newman N, Coyle TE "Elevation of platelet counts associated with indinavir treatment in human immunodeficiency virus-infected patients. Budesonide Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of Budesonide Systemic. Kopp JB, Miller KD, Mican JA, et al. "Crystalluria and urinary tract abnormalities associated with indinavir. Take indinavir on a regular schedule every 8 hours around the clock, unless your doctor tells you otherwise. Prezista darunavir US prescribing information. Tibotec Inc. Indinavir capsules are very sensitive to moisture. Keep them in their original container and leave the drying packet in the container. Breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; mild hair loss; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding. Are there any interactions with medications?
Olaparib: CYP3A4 Inhibitors Strong may increase the serum concentration of Olaparib. Management: Avoid use of strong CYP3A4 inhibitors in patients being treated with olaparib. If such concurrent use cannot be avoided, the dose of olaparib should be reduced to 150 mg twice daily. Agitation, bruxism, dream abnormality, dysesthesia, fasciculation, hypesthesia, neuralgia, peripheral neuropathy, tremor, vertigo, epidural lipomatosis, sensory loss, syncope, and peripheral paresthesia have also been reported. Oral paresthesia has been reported during postmarketing experience. Simeprevir: CYP3A4 Inhibitors Strong may increase the serum concentration of Simeprevir. Gilead Sciences. Viread tenofovir disoproxil fumarate tablets prescribing information. Foster City, CA; 2012 Jan. Your body can also make too much sugar. ViiV Healthcare. Viracept nelfinavir mesylate tablets and oral powder prescribing information. Research Triangle Park, NC; 2012 Apr. QUEtiapine: CYP3A4 Inhibitors Strong may increase the serum concentration of QUEtiapine. Management: In quetiapine treated patients, reduce the quetiapine dose to one sixth of the regular dose following strong CYP3A4 inhibitor initiation. In patients receiving strong CYP3A4 inhibitors, initiate quetiapine at the lowest dose and up-titrate as needed. New onset diabetes mellitus, exacerbation of preexisting diabetes mellitus, hyperglycemia, and in some cases, diabetic ketoacidosis have been reported in HIV-infected patients receiving protease inhibitors. However, no causal relationship has been established. Patients may require initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. Hyperglycemia persisted in some cases after discontinuation of protease inhibitor therapy. ONGLYZA was dosed once daily. Cardiovascular side effects have included myocardial infarction, angina pectoris, hypertension, and cerebrovascular disorder during postmarketing experience.
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Bortezomib: CYP3A4 Inhibitors Strong may increase the serum concentration of Bortezomib. If you miss a dose by more than 2 hours, wait and then take the next dose at the regularly scheduled time. However, if you miss a dose by less than 2 hours, take your missed dose immediately. Then take your next dose at the regularly scheduled time. Do not take more or less than your prescribed dose of Crixivan at any one time. Do not have any kind of sex without protection. Always practice safe sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood.
Drugs for HIV infection. Irinotecan Products: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Irinotecan Products. Specifically, serum concentrations of SN-38 may be increased. CYP3A4 Inhibitors Strong may increase the serum concentration of Irinotecan Products. Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children, US Department of Health and Human Services HHS. Guidelines for the use of antiretroviral agents in pediatric HIV infection February 12, 2014. Updates may be available at HHS AIDS Information AIDSinfo website. The atorvastatin and rosuvastatin doses should be carefully titrated; use the lowest dose necessary with careful monitoring during treatment with Crixivan.
Drospirenone: CYP3A4 Inhibitors Strong may increase the serum concentration of Drospirenone. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking first with your doctor. Gentle DL, Stoller ML, Jarrett TW, Ward JF, Geib KS, Wood AF "Protease inhibitor-induced urolithiasis.
Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. CRIXIVAN, an Antiretroviral Pregnancy Registry has been established. Potentially increased alfuzosin concentrations can result in hypotension.